My overarching goal is to evaluate the risks and opportunities of nutritional factors in enhancing neurodevelopment and host resilience to early-life adverse events (e.g. infection and stress). Our research use neonatal pigs as a translational model, becasue of broad resemblance between pigs and humans in many aspects, such as digestive physiology, components of immune system, anatomic structure of brain and perinatal neurodevelopment. Specifically, our current project investigates how unbalanced iron status in early life affects systemic and CNS iron hoemostasis, susceptibility to infections, brain energy metabolism, and social cognition using nursing pigs.